Monoamine oxidases (singular abbreviation MAO) (EC 22.214.171.124) are enzymes that catalyze the oxidation of monoamines. They are found bound to the outer membrane of mitochondria in most cell types in the body. The enzyme was discovered by Mary Hare in the liver, and received the name of tyramine oxidase. They belong to protein family of flavin containing amine oxidoreductases.
Locations of MAO-A and MAO-B In humans there are two types of MAO: MAO-A and MAO-B. * Both are found in neurons and astroglia. * Outside the central nervous system: o MAO-A is also found in the liver, gastrointestinal tract and placenta. o MAO-B is mostly found in blood platelets.
Function Monoamine oxidases catalyze the oxidative deamination of monoamines. Oxygen is used to remove an amine group from a molecule, resulting in the corresponding aldehyde and ammonia. The general form of the catalyzed reaction (with R denoting an arbitrary group) is: General Form of MAO Oxidations Monoamine oxidases contain the covalently-bound cofactor FAD and are thus classified as flavoproteins.
Subtype Specificities MAO-A is particularly important in the catabolism of monoamines ingested in food. Both MAOs are also vital to the inactivation of monoaminergic neurotransmitters, for which they display different specificities. * Serotonin, norepinephrine (noradrenaline), and epinephrine (adrenaline) are mainly broken down by MAO-A. * Phenethylamine is mainly broken down by MAO-B. * Both forms break down dopamine equally.
Yang seru buat orang awam, kalo pasangan kita punya MAO dalam tingkat tinggi, maka dia akan pasti suka kejutan, suka orang yang kreatif, inovatif, suka melakukan perjalanan jauh (or suka jalan2 dech), suka hal-hal yang baru, dan gak suka rutinitas. So, kalo ketemu dia atau mau ngajak dia bilang aja “LET’S HAVE FUN!”